Best practice for accessing the workarea in a multisite environment.
When working in a multisite environment, the best practice is to log into a specific site's workarea to make changes, rather than logging into the root site to make changes in a sub site.
For example, site.com is the root site. And, sitetwo.com is set up as a multisite. To edit sitetwo.com, the best practice is to log into sitetwo.com/cmslogin.aspx rather than site.com/cmslogin.aspx.
If you make changes in the root site for a multisite, it can potentially cause issues or limit functionality. If you encounter issues in a multisite environment, make sure you are testing in the proper site. If not, log into the correct site and retest.